Homeschoolers tend to do well in college b/c they're usually motivated, independent, and have done college classes already. By the time they're in high school, they're usually handling everything on their own. Also, their applications really stand out b/c they are so different. Most colleges have a dedicated homeschool admissions person now.
Home to High School to college, kids that I know did well. Their applications and high school experience aren't as outstanding usually as homeschoolers, but they are well-prepared for high school. Most of them did something different for high school such as boarding, magnet, etc.