I have been taking SSRIs and/or Wellbutrin since 2001. I am currently off all of them because the SSRI that I was taking is driving up my blood pressure and the effectiveness is wearing out. I have a hard time switching SSRIS and have a history of serontonin syndrome. So the doctor suggested that I stop taking them and I have stopped.
I am coping with the anxiety and depression through meditation and a lot of exercise. I meditate 10-15 each morning. I exercise every day. I also did a brief round of cognitive behavioral therapy to get ready for the switch and to pinpoint some of the sources of my anxiety. It was helpful.
I have a hard time just meditation because I have crazy brain and it goes all over the place. The mediation that I have found most helpful for keeping calm and centered is a metta mediation. There's an explanation of it here:
http://www.mettainstitute.org/mettameditation.html
For exercise, I alternate running days with yoga days. Besides promoting strenght and flexibility, yoga promotes mindfulness which also helps alleviate anxiety. Any exercise though will burn off some of the nervous, anxiety energy.