Hello
Multiple miscarriages is very difficult and can be such a roller coaster.
Getting pregnant yields a cautious private solitude often as you aren't ready to share what you wish were good news as good as a delivery of a baby.
If there's been no diagnosis of a genetic cause through testing previous babies,
and if you are open to looking at things associated with repeated miscarriages including possiblyy some of these:
your luteal phase, which ought to be 9-16 days past the "Peak" identified through charting....and 2 days of brown bleeding or spotting, or 3 days or more of spotting before your period starts
You might find an underlying cause by having a follicle ultrasound before ovulation, or finding the length of your post peak phase through a fertility coach, or instructor like a FertilityCare/ NaProTECHNOLOGY Practitioner
Here's some info on REPEAT MISCARRIAGE
Please forgive the medical name..
http://www.naprotechnology.com/abortion.htm

Peace as you find there's local help and hope and healing for healthy mom and/or information about yourself.

I was in the same position as you- secondary infertility after easy birth at 35. No indication of an issue in my blood tests. But 3 miscarriages and years of trying. IVF with PGS helped me with the egg quality problem. My RE didn't want to do it either but I'm so glad they finally relented and let me do PGS. I think their typical protocol is to start you with IVF first and then do PGS later. But I think it's kind of silly if it looks like egg quality is the issue and the patient is willing to pay for the PGS. In my case, they let me do PGS after a miscarriage where a trisomy was found and I hysterically cried in their office until they let me do PGS. Thankfully, the PGS helped me narrow down the embryos- of about 20 retrieved, only 2 ended up normal and growing until day 5. So without the PGS, I could have been implanting a lot of abnormal embryos and having a lot more miscarriages. Best of luck

Oops, meant PGS, not PGD.

OP, you could be me. I'm starting IVF with PGD now because of secondary infertility and four miscarriages. All our tests are normal, but we keep having miscarriages. Our RE says it's most likely egg quality, so PGD is the way to go.

Anonymous wrote:i don't see how IVF helps here. it can only get you to the point where you already made it 4 times on your own.

IVF helps because you can screen the embryos for genetic abnormalities which is likely the cause of the recurrent miscarriages.

i don't see how IVF helps here. it can only get you to the point where you already made it 4 times on your own.

Your RE sounds like he/she is trying to make money off of you. With 4 miscarriages you either have and egg quality problem (for which you need PGD) or a recurrent pregnancy loss problem (maybe low Vitamin D, or immune problems. This is assuming you have no lining or structural issues. Get all the tests the previous posters mentioned, but if everything is OK do PGD!

Did you do a full thyroid panel, also check for blood clotting factors? If you have no problems conceiving I would think IVF is a last resort. I would get a second opinion.

PGS will help you to rule out embryo quality as an issue. If you can afford it then it would be helpful.
If you have normal embryos which don't implant then it will open up other areas to look at.

OP, did you and your husband have your chromosomes karyotyped?

We conceived our first child without help, I was 36 and DH 34, 2 years later we began trying for dc#2 and have had 4 miscarriages. I have been to an RE and had all the preliminary tests done and nothing points to a cause. FSH is 10, AMH is 1.8, and DH has good numbers so my research seems to indicate egg quality as a problem, and RE suggests IVF but does not recommend PGD. Wouldn't PGD help pick the best embryo and decrease the chance of another miscarriage??