Even in American chains, there is a pretty wide range of sizes, especially since many hotels in desirable areas have not been purpose built.
I had an enormous room at the sheraton park lane, a good size room at the marriotts in grosvenor square and swiss cottage. If you're just using it for sleeping and aren't too worried about a tight squeeze, it sounds like any of them, plus the marriott county hall, would be okay.
Outside the familiar, unless you're spending a lot, it will likely be a bit too cozy.