Cinque Terre - Ligurian Coast, Italy. Combine with Paris, Nice, Genoa, Milan...
Greece & the islands.
I hear great things about Thailand with families.
Northern California: Yosemite and Napa, take a Julia Morgan tour in Berkeley, Children's Fairyland in Oakland, day trip to Muir Woods, Muir Beach and the Pelican Inn for dinner. Chez Panisse bistro. Big Sur, Carmel (more great architecture)
St Bart has lovely villas and great food, Saline Garden is a secret place to get an inexpensive rental near the best beach and restaurant on the island. Saba nearby has fascinating architecture and nature hikes.
My DH is heading to Phoenix and there is a lot to see re: Taliesin West, Sonoran desert museum, botanical gardens, SW cuisine, waterslide resort pools

Grand Canyon, Sedona. In NM you can stay at the Ghost Ranch.
I guess the kind of culture trip that would appeal to me right now (with a 6 and 4 year old) is NOT the same as what I would do alone or with DH - Turkey, Cuzco, Naples & Amalfi. Kids have been great on short nature tours but not prolonged museum visits...