Just as with DC metro area, you should consider your commute. If you both know where you are going to work, keep the commute time in mind when looking at neighborhoods.
My DH lived on the west side of Houston, off Memorial Drive. (Stratford HS). He hated it, but was a disaffected teenager!

It seems to have nice neighborhoods with decent schools, and a pleasant place to live. In-laws still live there and are happy with it.
Good luck, and escape to the Hill Country and Austin for weekends whenever you can!