Not a multifloor house currently, but here's what we do:
Daily: spruce up kitchen, take out trash and spot sweep/vacuum if needed
Weekly: full clean (kitchen, bathrooms, de clutter, floors)
We occasionally will deep clean as well, and we try to purge junk 1-2 times a year.
Having enough organizing space helps with clutter as well. And for laundry, its fairly quick to toss in a load in the evening and switch it before bed.