We've never filled the syringe with air and I've had 35 days of shots. I did experience bruising, a slight rash, and a bit of swelling - all of which my doc said was normal. Talk to your nurse but I wouldn't worry.

I just did my first Lupron shot, and I have questions (and CFA doesn't open for 30 min). In my nerves, I forgot to fill the syringe with air before putting into medicine, then ejecting air and refilling with meds. Is that a problem? I just filled with medicine. I'm also swelling a little bit at the injection site. Is this a big problem?