I have used them twice. Once we rented an apartment in San Francisco for a week for our immediate family and the other time we rented a lake house on Seneca Lake in the NY Finger Lakes region for a family reunion. Had amazing experiences both times. As far as the other parties being trustworthy, I don't know. The first time, the owner had lots of testimonials and references and seemed just as cautious about us as we were about him. The second time, I was much more relaxed about it and it turned out fine--amazing, actually. You are taking a risk on some level, I guess. I see vrbo offers rental insurance. Might be worth the peace of mind.