I felt very PMSy (mainly bloated) starting a few days before the beta test. BTW, I took a HPT the day before the beta and it was negative, so don't necessarily rely on those results.

I did three unsuccessful TI cycles with Gonal F and trigger, and one successful IVF. During the 2ww of the TI cycles, I always had sore nipples from the trigger, which went away before my beta, despite progesterone supplements. On the successful IVF, I also had sore nipples, but they did not go away. May have gotten a bit less than initially after trigger, but never subsided like during the failed cycles.

I know this is an old post but just wanted to share that I am 3dpiui and experiencing very sore nipples. I was on gonal f injections but no trigger shot since I had a natural surge on CD8. Anyone experience sore nipples after iui without trigger shot??

Thanks to the PPs. OP here-I am not on progesterone this cycle. I was last cycle to prolong my luteal phase while on vacation, but never had sore breasts or nipples, which I was expecting. Who knows. It is all so confusing. I keep going back and forth on testing. Beta is Wed. We shall see.

Hang in there, OP! The 2WW is truly terrible, and I do the same thing analyzing ever symptom. When I was truly pregnant, the sore boobs didn't really started until a few days after my beta. If you are taking progesterone, that could be causing symptoms. BUT you certainly could be pregnant, too -- that's the whole point of the IUI and drugs! Good luck. Let us know. (P.S. I don't know where you fall on this, but I am a big believer in HPTs to relieve the stress of the 2WW. You should get an accurate result if you hold out a few more days.) I myself an scheduling a vacation for 3 days of my 2WW, which started today, and hope it help.

To be fair I had Gonal-F plus Clomid kicker, and my ONLY symptom was those stupid Clomid hot flashes. I didn't think I was pregs, and in fact, had a negative preg test and some cocktail indulgences at 15DPO. Had my beta at 16DPO and low and behold... baby is due in three weeks.

Please tell me what your 2WW symptoms were. I am seriously going nuts. This is the first time I have been hopeful and it is my 4th IUI cycle, but first with injectibles. I am 9DPO and think I am really going to lose it this time if BFN. I am trying to hold it together. I think the reason I am so hopeful is I have had sore nipples the entire 2ww thus far and this has never happened before. While they are not as tender as right after the IUI, they are still sensitive to touch. Beyond that I have some real mild cramping, but nothing intense or constant. Thanks for any hopeful comments. I am usually really good at keeping my emotions in check and not analyzing every symptom, but for some reason this cycle I am a complete nutbag.