You may not need the full dose twice a week, and especially not the two-week daily “loading dose” often recommended—many women don’t and are irritated by that amount.
Many apply a pea-size amount topically/externally, and a pea-size amount internally, twice a week.
Also, once the tissue begins to improve, the cream may not absorb as readily (which might also improve side effects).
I think the gastro upset, especially at higher doses, can happen at first, but it probably shouldn’t continue long-term—check with your doctor if it does.
https://www.goodrx.com/estradiol/applying-estrogen-cream