All the restaurants we frequent when in town have to go packages (like 1703 Restaurant), but I am told that Sir Winston is open downtown:
https://sirwinstonrestaurant.com/

Maybe with kids the Fourth Street Filling Station is better. It should be open too: https://www.theoldfourthstreetfillingstation.com/

This is extremely random, but it never ceases to amaze me what people on this site know about. We have friends who just moved to Winston Salem and we are going to go down and take them out on Thanksgiving. (Eating out will just be easier because they aren’t totally settled in). Any recommendations? We’re 4 adults and 3 kids ages 11-18. Thanks!