I'm on Ozempic compounded and have no idea what you all are talking about with gas and shits. That hasn't ever happened to me. I'm more constipated than ever.

I don't eat much on shot day. And I try to take it later in the day. Increased water and protein are the best. In the past, carbs (like crackers) always cured nausea but not on semaglutide! Carbs make me so sick. Fatty food is a total no go as well, but some of that is because I've lost my appetite and fatty food looks soo unappealing now that it makes me sick looking at it.

Shot day diet matters. I’ve found that I need to do my shot in the AM and focus on eating protein, electrolytes, and easily digestible carbs that day. Avoid fatty food and anything super fibrous. Like, I don’t do salad on shot (shit?) day. Take a probiotic for the gas, pickles help too.

What are you eating? It's not enough to tell us you ate healthy. What specifically did you eat?

I ask because I'm eating a low carb, high protein diet (I started this diet about a month before I started taking zep, so maybe all the nausea inducing stuff was out of my system), but make sure I have plenty of fiber throughout the day. I also drink coffee. I've had zero stool or nausea issues.

My doctor suggested an OTC nausea medicine - meclizine - but I haven't needed it.

Also are you taking real zepbound or fake? The additives in the compounded stuff could cause these symptoms, too.

Ask your doctor for a nausea med.

I'm on Zep and take Zofran at least an hour or two before taking Zep.

This is the first glp-1 thread that I’ve read which hasn’t made me envious ☺️.

Hope this is just initial adjustment and that you feel better soon, OP!

Inject in your upper thigh to avoid side effects.

Ditto that my first 4-5 days was the worst where I felt low grade nauseated but by the end of the first week I felt MUCH better. was on 2.5 for 1 month, then 5. I did have a bit of indigestion when I increased the dose but it was mild and only a couple of days.

My first month lab work showed really significant (and good!) progress on all my indicators. That part has been really encouraging. Good luck

My first few days were really rough also, but it got easier as my body adjusted. I stayed on 2.5 for 4+ months (and lost steadily during that time). Don't despair yet - manage the side effects and see how things go over the next week or two.

Good luck!

My first week was by far my worst. Hopefully for you, this too shall pass.

People on this forum suggested Boiron NauseaCalm tablets and they helped a lot. Obviously you're already taking zofran so maybe the homeopathic route doesn't make sense, but hey, couldn't hurt to try.

I also really depended on ginger candy.

Zofran will constipate you; make sure you take countermeasures.

Drink water and try and eat snacks, don't overeat.

Make sure your dose was correct. Different pharmacies have different dosing, requiring different injection units.

Don’t worry about calories as much as protein and electrolytes. If you prioritize those, you’ll probably feel better.

Just started on 2.5 tirzepetide injection on Sunday. Felt bloated on Sunday and Monday but pepto bismol helped. I forced myself to eat about 1200 calories (healthy) and drink water. I woke up today with the need to have nultiple poops and nauseau and dragged myself into work. Took a zofran and still have mild queasiness.

Any tricks to help with side effects? I may need to just be fat and happy--