Yes, it's well-known that Zyrtec is the anti-histamine that makes people sleepy. It's also very effective, but some people need to take it for a week before getting used to the drowzy effect. When I was a teenager and other histamines didn't exist, I had to wait 2 weeks for the drowziness to go away. I took Zyrtec for the entire spring due to severe pollen allergies.