Southwestern CO--hiking, off roading with Jeep rental, visit Mesa Verde, Million Dollar Highway with stops for hiking/views, Canyoneering, Box Canyon Falls, Via Ferrata, Black Canyon of the Gunnison --we did this trip flying into Durango and out of Montrose. Teens would love to go back and spend a whole week in Ouray (we split between Durango and Ouray)
We have also based in Bernese Oberland and done all the things in Murren/Wengen/Grindelwad, etc, mostly hiking but also paragliding, Via Ferrata again, ebiking.
Another favorite is the Rafiki Safari Superlekker in Costa Rica. Such a great place with great owners.
https://rafikisafari.com/wp/superlekker/