I'm adding some that others haven't mentioned.
Dallas and Fort Worth have quite a few great museums, some of which were mentioned by others. I particularly like the Kimbell Museum in Fort Worth (which is located near several other museums) and the Sixth Floor Museum in Dallas (which documents the life and death of JFK in the building from where shots were fired).
I also recommend the Strong Museum of Play in Rochester, NY. We've visited with young kids and teenagers and enjoyed it both times.
A more offbeat recommendation is the Mutter Museum in Philadelphia.
https://muttermuseum.org/
It's local, but if you haven't visited the American Visionary Art Museum in Baltimore, you should check it out.