Anonymous wrote:I know that several doctors have said that the Genesight testing is not helpful/evidence based at this point. But could the Genesight testing screen for this potential side-effect (psychosis) at all?

No

Anonymous wrote:New study

https://psychiatryonline.org/doi/10.1176/appi.ajp.20230329

"A dose-response relationship was observed; high doses of amphetamines (>30 mg dextroamphetamine equivalents) were associated with 5.28-fold increased odds of psychosis or mania."

I mean … duh?

—someone who has, unfortunately, struggled with a condition that causes mania

Anonymous wrote:People with psychosis or mania need a higher dose. How is this surprising?

But they only saw this impact on the hospital patients taking adderall, not concerta.

Anonymous wrote:People with psychosis or mania need a higher dose. How is this surprising?

huh? adderall is not a treatment for psychosis.

Anonymous wrote:People with psychosis or mania need a higher dose. How is this surprising?

This.

Anonymous wrote:That seems like a really high dose? My kid takes a different med, but the dose is much lower.

Its on the high end; 5mg is typically the starting titration in children, 20mg is the "typical" adult dose. 40mg is the FDA's suggested maximum. Its dosed at up to 60mg for severe ADHD and narcolepsy.

Its interesting they found methylphenidate didn't have the same association.

People with psychosis or mania need a higher dose. How is this surprising?

Anonymous wrote:That seems like a really high dose? My kid takes a different med, but the dose is much lower.

I don't think so. It's been years since DS was on this med, but i think starting dose is 10mg for kids in K.

That seems like a really high dose? My kid takes a different med, but the dose is much lower.

There is no free lunch.

Ugh. Has anyone read the whole study? I’m wondering if this is an issue for kids that have been on the medicine long term without issues or more of an issue for kids that have adverse side effects with it?

I know that several doctors have said that the Genesight testing is not helpful/evidence based at this point. But could the Genesight testing screen for this potential side-effect (psychosis) at all?

Not surprising to me at all based on our experience. But I remain grateful this medicine works wonders for others.

New study

https://psychiatryonline.org/doi/10.1176/appi.ajp.20230329

"A dose-response relationship was observed; high doses of amphetamines (>30 mg dextroamphetamine equivalents) were associated with 5.28-fold increased odds of psychosis or mania."