You just do it! It’s called life and there isn’t a manual. If you’re asking it’s time.

My job is flexible and the people I manage are great. But, I’m feeling more and more annoyed with my direct supervisor. In my 20s, I job hopped regularly. But now, I’m in my late 40s and I’ve been doing this for a long time. How do I know if it’s time for a new job?