I would also look at the AC hotels in Spain. They are part of Marriott but they originated in Spain and there are many.

I stayed at the Renaissance in Barcelona. It was very good, the rooms were small, but that's true for most mid range hotels in Europe. But breakfast was excellent, and the location was right in the center of things.

Hotel de Arts

The one that's closest to the location you want.

What location do you want

Location is key