A sibling has bipolar disorder and has had periods of psychosis that require hospitalization.
Her counselor recently encouraged her to take a genetic test for the MTHFR variant. Apparently people with this variant are more prone to psychiatric disorders, including bipolar and periods of psychosis. My sister just got her results and has double helix mutation. They now want her on a pretty high dose of supplements to counteract it and believe it will immensely help her.
I found one article via Journal below, where this research is validated. Wanted to see if anyone else has heard of it or had experience with doing high-dose supplements to make up for this variant and having a positive impact on mental health? It's interesting.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433753/