58F here with Osteopenia, so I can relate.
Heavy is different for everyone. But basically it's feeling almost maxed out at around 10th rep, and trying to get to 12 reps. As you do this on a regular basis you will have to continue to push yourself so the weight remains challenging. You should be focusing on the "push/pull" exercises: rows, bench press, TRX, leg press, squats, lunges. I lift 3 times a week, on the other days I go to barre which really helps me with balance and core strength. I also love walking. I live in a coastal town with a lot of hills and stairs. I just bought a 12 pound vest which I wear on my 5 mile walks up hills and stairs, and also on the sand - it literally kicks my butt.
Lastly if you listen to podcasts I love JJ Virgin's podcast, she is very relatable and she is very knowledgeable on all things nutrition and fitness - she had a recent episode that is on this very topic "Strength Training for Women Over 40 Made Easy | Ep. 586"
https://jjvirgin.com/main-podcasts/