Anonymous wrote:
Anonymous wrote:
Anonymous wrote:Just thought I’d chime in with Schoolcraft experience. He will not give you a protocol or anything like that, so it’s not worth it unless you are willing to go through with their extensive testing. He also started off suggesting donor eggs for me, which ehhh I was 33 with one early miscarriage from a fresh transfer and no other blasts from two IVF cycles. I pushed back though and pointed out my other results suggested something else was going on and he actually did agree and said I was like one of the few people he would actually not recommend donor for (even though he just did at the beginning of the call ….). So yeah he definitely just recommends donor to everyone. We ended up switching to SGF because it was March 2020 and we couldn’t travel. We ended up with 8 PGT A normal blast across 2 rounds with a different protocol. (Some miscarriages later, a live birth and some in the freezer). So yeah protocol and lab matter and honestly I don’t think you really know until you try. Good luck!
Interesting. He also immediately knocked the Cornell lab as being inferior to his when we first spoke and suggested my outcome (with many blasts) was unusual, even for being 40+ at the time. He could be right that not all labs are equal in culturing blasts but I succeeded w/ fresh day 3’s after multiple rounds with tons of blasts. Some errors occur in vitro and culturing to blast hasn’t improved the live birth rate of IVF. CCRM subsists on PGT testing because it supports their stats when they find PGT normals via donated eggs or women who rapidly produce normals within the first 2 cycles. This is why, per their geneticist, they’ve adopted a stance of suggesting donor eggs to any and all women who can’t “find” normal embryos after two consecutive cycles. This is no way evidence based and I personally know women who cycled 5 times (3 with CCRM) to find a normal embryo or who like me just stopped testing.
PGT testing can require multiple needless cycles when potentially normal embryos are trashed based on sampling 5 cells from the future placenta alone. Schoolcraft has a huge chip on his shoulder and rivalry with RE’s who threaten his corporate model because they are outspoken about the limitations of PGT testing. For reference, Stanford has a trial called TAME determining the efficacy of non FDA approved testing modalities like PGT. When he learned that I’d completed a cycle with one of his arch nemeses after first consulting him about my early PGT results, he got butt-hurt and told me not to bother with my own eggs. I succeeded with an RE who encouraged me to keep cycling and who lectures prolifically about the limitations of testing.
There have been reviews by women in which they were told Schoolcraft would only take them on if they agreed to testing.
Just gross. I’m glad his panel is full and definitely recommend going with anyone else but him if still looking at CCRM.
Yes, this is a really good point about how much CCRM pushes their embryo testing (which is supposively so much better than PGT-A). I had forgotten about that. Also I totally agree about no testing if you aren’t getting blasts. I ended up getting a bunch so it made sense, but even so I wonder if it was worth the cost with everything that is coming out now.
I was perhaps an oddball case of a woman over 40 who was able to produce tons of blasts but each batch of 6-10 per cycle kept resulting 100% “abnormal.”
Not just abnormal, but 3+ errors in each (complex). I had a hard time convincing most RE’s to transfer day 3 embryos because it’s virtually considered antiquated when you an produce blasts. I’m grateful to have found an “old school” RE who believes in trying different protocols, believes in transferring day 3’s even for older blast producers, and isn’t married to testing. I adore the old dudes of reproductive endocrinology.
Schoolcraft who is neither an old dude or youngster of the field, doesn’t believe protocol has any impact based I think on internal data. He also first shunned Cornell for his perception that they were doing tons of day 3 transfers “until recently” (untrue), while his lab is light years ahead. Again, his lab is probably awesome for some tough cases but the old way of doing things (in Schoolcraft’s words, “going back to the 1970s”) is what worked even for a prolific but older blast producer like me. I think this is in part because 80-90% of eggs are aneuploid in the early 40s and sometimes “high load” day 3 transfers are what works despite current blast inclined IVF culture. The data show that in older women, most untested day 3 embryos won’t even implant so it’s not a huge higher order multiples risk. My MD at Cornell cited a statistic that at 41, my odds of no-normals per batch with the number of blasts I had was like 1 in 5 (sadly not true). I think this is why Schoolcraft first suggested it could be Cornell’s lab, but later decided it was my crappy eggs. There is so much disagreement in the field and so much they still don’t know about the biology of human embryos.
Getting second and even third opinions in a field with an unchanged efficacy (live births) despite perceived advances and with so much yet to discovered is an absolute MUST.