Reply to Getting on GLP-1 after doctor says no

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[quote=Anonymous][quote=Anonymous]The rate of pancreatitis with GLP-1 receptor agonists is generally low, with studies showing rates of approximately 0.4% to 2.2%, and some large clinical trials find the incidence to be similar to placebo groups. While early reports suggested a higher risk, more recent, larger studies have shown a low rate and some evidence suggests GLP-1s may even lower the risk of recurrence in patients with a history of pancreatitis. The risk is slightly increased with certain factors like a history of type 2 diabetes, and some real-world data have shown a higher association compared to other drug classes, though the absolute risk remains low. [/quote]

Other studies show it’s higher and in people who are on more potent GLP 1s with a history of heavier alcohol use or smoking who are drinking or smoking while on a GLP 1 that risk will go up. With GLP 1s in the wild and people titrating up and down and microdosing and not under the care of a doctor or under the care of a doctor but not taking the lifestyle requirements seriously and getting regular checks (even though AKI can happen without warning) there are going to be a lot more complications.

You have to be honest about your medical history to be part of a clinical trial and you are closely monitored. A medspa or hers is not going to tell you to eat more fiber or more protein, lift weights and exercise, drink more water every day (and if you have no energy why would you listen if you are really tired and don’t want to workout or drink water?) or even to titrate more slowly, all to avoid potentially life threatening complications.

And Big Pharma has been known to understate risks. Look at OxyCodone. In all the pharmacy studies it was shown to be way less addictive than morphine or heroine and then we had a nationwide opioid crisis. [/quote]

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