Reply to NIH Study regarding HRT and BReast cancer

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[quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous]Progestin and progesterone is not the same and the latest findings are that micronized progesterone seems much safer—but more data is needed.[/quote]

Here’s the citation:
Conclusion: Although menopausal HT use appears to be associated with an overall increased risk of breast cancer, this risk appears predominantly mediated through formulations containing synthetic progestins. When prescribing menopausal HT, micronized progesterone may be the safer progestogen to be used.

https://pubmed.ncbi.nlm.nih.gov/35675607/[/quote]

I posted the above, reposting for the “scientist.” (I’m also a trained researcher but not related to medicine.)

To the person/s claiming there aren’t different types of progestins/progesterone, that is false. There are, and micronized progesterone, which is identical to what the body produces, is taught not to raise breast cancer risk. Studies are ongoing but the early indications are in that direction.

Someone else posted correctly that previous studies, which relied on synthetic progestins raised bc risk from 4.1% to 4.5%; however, even in those studies, overall mortality was lower in the treatment arm (group).

The best thing really is to pick a provider from Menopause.org and ask that person all the qualifications you have. So many posters on this thread are authoritatively making s#!t up.[/quote]

Good try. These were Swedish women so very homogenous unlike US populations. The study results are not delivered by age or by onset of menopause and so people 50-75 were lumped together. That's a problem b/c the NIH study that started this whole mess was based on people over 62 where a tiny effect was found. That same effect was not found in the younger cohort.

It's semantics that there's only one HRT. I would argue that two hormones versus one is a different type of HRT. I would also argue the same about the different delivery systems. Why so hostile? [/quote]

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