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[quote=Anonymous][quote=Anonymous]To the person who continues to insist that the generic is EXACTLY the same it is not. Generic drugs do have the same ingredients in the same dosage in the same delivery system (i.e. pill). They do studies to determine that these generic drugs are safe and effective however when they determine that a drug is bioequivalent they are approving it within an "acceptable range".  For example the drug is approved to be "the same" if it has 80-120% the absorption of the origional molecule.  For someone who is switching from a drug like concerta to a generic, this range can have no impact or a significant impact.  Also, the formulation of brand name Concerta is specially designed to deliver the medication over a period of time.  Generic Concerta (at least the Canadian version) does not have this specialized release system (even though it contains the exact same ingredients) thus changing the way the medication is delivered to the body.  I am not saying that generics are not safe or effective. They do contain the same ingredients, at the same dosage however because of the "acceptable range" requirements that the FDA considers safe they may not be EXACTLY the same as the origional molecule.  It is absolutely not in your head.  Many people have changed from Brand name to generic Concerta and have not had the same results.  [/quote]

Modest degrees of variability are commonplace.  Think about it - a single pill in one patient might take will be absorbed differently in different patients based on their diet and metabolism, and one pill might have different effects on, for example, a 90 pound Asian woman than on a 250 pound Italian man. We dont worry too much about this sort of variability, but you really want to pay tons of extra cash despite the insignificant differences between generic and brand-name Concerta? The FDA has a designated class of drugs, call Narrow Therapeutic Index drugs, where very small degrees of variability do make a difference. Concerta is NOT in that category. So please, if your doctor writes a prescription, get the generic. It will work just as well as the brand-name on 99.99999 percent of patients and save them a ton of money.[/quote]

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