Reply to is RKFJr's "Tylenol(TM) causes autism" just a shakedown for extortion money from the company?

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[quote=Anonymous][quote=Anonymous][quote=Anonymous]

https://www.mountsinai.org/about/newsroom/2025/mount-sinai-study-supports-evidence-that-prenatal-acetaminophen-use-may-be-linked-to-increased-risk-of-autism-and-adhd

“Our findings show that higher-quality studies are more likely to show a link between prenatal acetaminophen exposure and increased risks of autism and ADHD,” said Diddier Prada, MD, PhD, Assistant Professor of Population Health Science and Policy, and Environmental Medicine and Climate Science, at the Icahn School of Medicine at Mount Sinai. “Given the widespread use of this medication, even a small increase in risk could have major public health implications.”[/quote]

So what? The highest quality studies show the correlation disappears with sibling controls (look at women who took Tylenol for one pregnancy but not another); this suggests that the correlation is due to other factors such as the underlying reason for taking Tylenol rather than Tylenol itself.

ACOG:

https://www.acog.org/news/news-releases/2025/09/acog-affirms-safety-benefits-acetaminophen-pregnancy[/quote]

So what? You are wading in the same murky waters of findings that "suggest" and "may be linked." All but a couple studies are based on a mother's own reported usage of acetaminophen (and other analgesics), existing health problems and other information, a country's diagnostic capabilities, and the use of sophisticated statistical techniques to analyze the data. The limitations of the Swedish study, linked to in your ACOG media release, are addressed in other studies, including:

[url]https://pmc.ncbi.nlm.nih.gov/articles/PMC12429359/[/url]

"However, this study has two limitations that impact its ability to quantify APAP dosage [29]. First, the primary exposure metric in this study was the ever-use of acetaminophen. This neglects to quantify dosage. Second, because its secondary exposure metric quantified APAP use through prescription dispensations, it does not account for over-the-counter APAP use. Fifty-four percent of pregnant women use over-the-counter acetaminophen, according to one Iowa-based study [32]. Further, past research shows that prescription dispensations do not always reflect actual use. The mean implementation adherence among pregnant women was 72% in one study, and another study found that prescription guidelines compliance among Danish pregnant women was 43% [33,34]. With these two limitations, the study cannot accurately estimate APAP usage. As previously mentioned, longitudinal studies must quantify APAP usage since a critical point of exposure may exist [23,24,29] (Table 1). Although this study explores confounders through sibling control analyses, the lack of APAP dose quantification hampers its ability to establish the presence of absence of a correlation between the two variables."

Press releases like the one you provided are designed to simplify and manage messaging of a complex issue, just like your own comment. [/quote]

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