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[quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous]Good thread

I'm 33, husband 31. Unexplained for 4 years. 3 IUIs, 1 IVF resulting in OHSS requiring that we freeze all our embryos (9 all grade AA). First FET was a BFN. Second FET was a chemical. We then took a 2 year break as I was a total wreck emotionally. As a last minute thought we did PGS before our 3rd FET. No longer unexplained infertility... every single one of our "perfect" embryos were chrom. abnomal (most had trisomy 21). We just sent second biopsies to Natera to determine if it was maternal or paternal. They couldn't figure it out. We then did ANOTHER fresh IVF as a shot in the dark for normal embryos... (again, we don't know if we'd need an egg or sperm donor) Just got my Day 6 report that 3 made it to freeze (of 16). We immediately biopsied and are waiting for the results. As there's no way of knowing if it's an issue with me or my husband (and both our karyotypes are normal), we'll have to move straight to embyro adoption.

Miserable. Isolated. Alone. Overweight. In debt. OVER IT. [/quote]

You are not alone.  [/quote]

+1 Nope. You are not. Though we went through three egg donors and multiple surrogates before finally insisting on PGS. Turns out our "perfect" looking embies - both with my OE, and with younger, ideal age egg donors - were all aneuploid. My soul burns to think of all the money we lost and heartache we experienced on transfers that were never going to work b/c our embies were terrible even when they looked AA. But the REs kept telling us to "save money" and not do PGS, not worth it because we had an egg donor, etc. (Never occurred to them that DH was the problem!) Finally, we insisted. 80% aneuploid embies with a 20 yo egg donor and DH's sperm. Thankfully, there were some normal embies, but it sure explained a lot. Our GS is now 15 wks pg, which, even then, took two tries. We also have normal karyotypes and DH's sperm looks fine. Clearly, it's not.

The only thing I regret about our eight years in the infertility trenches is not insisting on screening donor egg embryos from the start. We spent six figures trying to save ourselves $5,000. Makes me sick.[/quote]

OP here (of the Unexplained comment...also, I forgot to had that my husband and I had normal karyotypes). Thank you to those who commented that this also happened to them and best of luck to pregnant GS. Please ladies, PGS may save you months or years of heartbreak and certainly may be worth the $$.[/quote]

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