Reply to How, exactly, does Ozempic work?

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[quote=Anonymous]I've been on Tirzeptide for 8 weeks to lose 20-30 pounds I've gained from a combo of Perimenopause and a new thyroid diagnosis.  I've intentionally kept my dose low to avoid full appetite suppression as that isn't sustainable long term. So, I still have an appetite, it's just less than it has been the last couple of years.  I've lost 14 pounds so far which has been great but honestly, the biggest benefit has been the decreased inflammation. My body was in constant pain prior to going on the GLP1. Apparently, decreased estrogen does a number on our bodies, including increasing cortisol and inflammation. I'm prepared to supplement with estrogen but my doctor would like me to wait until I'm no longer menstruating.  My plan is to titrate down once I'm at goal weight and then only do a microdose 1x a month or so. I work in health care and these meds are FASCINATING from a precision medicine perspective. I'm also motivated to microdose longterm because GLP1s may reduce dementia risks, which my genetics make me more susceptible to. [/quote]

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