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[quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous]so normal PGS on a batch of embryos is $5-8,000.

1) you're talking about trusting a unknown startup with a critical medical test that you cannot do-over, at a cost 5-9 times what a regular PGS should be

2) if you're considering this on already extant embryos, you are likely going to kill the whole batch with the thaw/sample/freeze process. people only consider doing this when there is a deadly genetic issue that they are trying to avoid.

3) economic status is still the best predictor of  success. invest the $40k now in a 529, provide love and support to whatever kids you get.
[/quote]

They are analyzing the SNP data from the lab where my clinic sent the biopsy samples. This company also collects DNA from both of the parents and then uses the SNP to reconstruct the entire genome for every embryo. I don’t need to biopsy again, I already have the data needed to analyze this information. Yes, parental SES is the best predictor of life outcomes, but genes matter. There are already studies that have been conducted (and replicated) where researchers used genetic scores to predict social mobility and economic success among siblings.[/quote]
Gullible much?[/quote]

You are not up to date on the research.  https://www.pnas.org/doi/full/10.1073/pnas.1801238115
These people did not provide me studies as references. I was already aware of this research and was actively looking for someone that might be able to do this for me. It’s just hard to find people that do it because it is a controversial service.[/quote]

it's also hard to find people willing to do CRISPR edits on embryos...

look, you appear to have made your mind up. good luck![/quote]

I have not decided yet, because I’m not sure how to evaluate whether some random company offering the service is credible.  This is categorically different than CRISPR because nothing is being changed. I’m just looking at additional information. [/quote]

The service is likely not credible, because otherwise we'd have a commercially available 23andme-like service that would assess IQ for adults based on genetics. Since we don't have a good mapping in adults where one can evaluate/compare the data, anything for unborn embryos is not likely to be any more accurate than a coin toss.

But as mentioned, you have to pick *some* embryo to go first. if $40,000 isn't important to you (maybe you'd have to forgo a second birkin bag this year), or if you feel good about paying to contribute to commercial research endeavors then sure, proceed. sometimes there is enough material left after the PGD to do a secondary analysis, sometimes there isn't.

I paid about $20,000 extra to participate in a shared risk IVF program, not because I wanted/needed to get my money back, but because there was a streamlined process to do another (up to 6) round of IVF if I didn't get to a live birth. The house won financially, but I got my desired live birth. everyone walked away happy. You're asking if $40,000 for an experimental, unvalidated service is worth it. Only you can answer that. Maybe also get a tarot reading for each embryo and see which one has the best reading.[/quote]

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