Reply to Screaming into the void...recurrent pregnancy loss

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[quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous]Yes keep advocating for more testing. You might want to pursue immunological testing. Have them check your levels of natural killer cells. Some people have an over abundance of them and others have a normal amount but happen to have overly active natural killer cells who mistake a pregnancy for a foreign invader and sadly, attack the pregnancy. There are various ways to treat this. Many women with recurrent miscarriage and elevated natural killer cells have found that being on a low dose of prednisone helps to keep their pregnancy being attacked by natural killer cells. I am so sorry for each of your losses. I hope you will find a path forward to an eventual successful pregnancy. What a challenging journey this is.  If you aren't already working with a therapist, you may want to consider working with a therapist who provides infertility counseling. Please be kind to yourself as you persevere on your uncertain journey. My thoughts are with you, and I truly hope that brighter days are ahead for you. [/quote]

This is what I am doing. I'm starting the testing process with a RI. He suspects I have an undiagnosed clotting disorder based on the timing of my losses, but isn't ruling out other immunological causes. Literally I've been tested for everything. A huge panel of autoimmune diseases, A1C is fine so my OB refuses to put me on metformin. Haven't been tested for NK levels so that's on there, but I've had lots of genetic tests and absolutely nothing shows up. Thyroid was under 2 when I lost the last baby, heart stopped suddenly.

Really appreciate your kind words. It's been a total demoralizing journey. My worst nightmare growing up was the fear of suddenly finding myself totally infertile. [/quote]

Recommend getting the Dr. Beers panel, which will include immune issues and obscure blood clotting disorders. I've had 3 losses in the last four years. Lost my only good tube with the first loss. I've miscarried one PGT-tested embryo, failed transfer of another top quality PGT-tested, and miscarried a day 3 that was genetically normal. During the time, we found I have a blood clotting disorder, which isn't a surprise because of the severe preeclampsia with my son very early. But I was on blood clotting meds during my two miscarriages. After the last one, I was forced out of my clinic (it closed) and went to CFA because I was out of answers. She chased down EVERYTHING. We found an additional blood clotting disorder no one tested for (MTHFR) and obscure immunological factors (HLA and KIR matching, Th1/Th2 ratios), which can also explain what happened with my son, and another uterine issue. I don't know if it will work yet, but we're moving onto IVIG and other immune suppressant drugs.

I agree with how utterly demoralizing it is. On top of that, I don't make many eggs so every embryo is precious and it sucks to finally get pregnant and then lose it, and the problem is all me.[/quote]

early ASA lowers pre-eclampsia risk[/quote]

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