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[quote=Anonymous][quote=Anonymous][quote=Anonymous]New poster here.  I have repeat implantation failure and I got immune testing and was found to have immune issues big time.  I'm struggling with secondary infertility though.  I have one child who I got pregnant with easily the natural way.  When he was 6 months old we started TTC again.  Fast forward two years later, plus several failed infertility treatments later, and I never had another pregnancy (no miscarriages or chemical pregnancies).  All my testing and my DH's testing was completely normal except for mild decreased ovarian reserve, which several REs weren't even sure I had (because my AMH tests and my AFCs never matched up).

But it made no sense to me that I got pregnant on the first try/healthy pregnancy and delivery and then started TTC when my son was 6 months old and nothing at all for two years.  Then I remembered that several times during implantation time I would get weird flulike symptoms out of the blue (shaking chills, stomach cramps, nausea) for three hours and then it would all go away.

So I got all the immune testing done and it showed that my immune system is completely overactive and I have high/abnormal results for everything.

So I would suggest getting the immune testing done.[/quote]

Wow, what a difficult time for you.  Thank you for sharing your story.  So do they think you developed immune issues after the first pregnancy, or just got very lucky somehow with having your first child?  I have a long history of doctors trying to figure out if I have an autoimmune disease because of recurrent joint pain among other things, but nothing has ever been found for sure (definitely not RA, nor lupus or fibro, etc), but hearing these stories I'm wondering more and more if there's something latent that wouldn't impact my life but is majorly impacting my fertility.  Definitely going to pursue testing.  Thanks for this information.[/quote]

The theory is that a first pregnancy, especially with a male fetus (which I had), triggers an underlying disposition to the autoimmune issues. (Of course plenty of people have similar issues without having a first pregnancy.) I have a clotting factor too which in retrospect makes sense -- I actually wound up in the ER with a minor clot 4 days after my son was born, but I did not realize there was a real issue until Abbasi ran her tests. Everyone said the clot was from the IV during labor and I'm sure it was, but now that I know there is an issue, it makes sense that I was more likely to develop a clot from the IV or whatever else.

I would definitely get the tests done before you proceed with any more cycles. If you're lucky nothing will turn up. If something does turn up, you can decide on whether and how to treat it before you spend more time and money on cycles that may be doomed if you have major issues and don't get them treated. I am definitely not out of the woods, and in fact have to get blood drawn every 2 or 3 weeks throughout the pregnancy so the various meds I'm on can be adjusted. But I am reassured that the docs are trying and I am not just out on my own like my previous pregnancies.[/quote]

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