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[quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous]Ohhhh I’d to PGT-A. Age 38: labs were great, 15 mature eggs, 9 blastocysts …2 euploid. Even with a great blast rate and beautiful embryos many were deeply flawed. Not low level mosaic. Bad. I would NOT want to “test” them by undergoing multiple heartbreaking, time consuming transfers.

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Normally I advise against PGS testing but in OP's case she needs to know if she needs to do more retrievals or proceed with transfer. Her # of euploid embryos per egg retrieval is probably less than 0.5. She can waste precious time miscarrying. Either PGS or go to donor eggs [/quote]

Can you elaborate more? My RE said my amh was much higher than average for my age and she’s expecting a lot of eggs. I don’t have pcos. We did all tests possible for both partners. I understand what you’re saying though and thinking maybe we should test to stay on the safe side. Main concern: could we lose a potentially good embryo by testing? Ie false positive [/quote]

i don't think AMH correlates with percentage of euploid... which is the concern that you'd be doing testing for.  I would determine your personal risk tolerance for a child with a chromosomal issue (e.g. 2 of my 5 blasts had down syndrome) and your risk tolerance for miscarriage.  One of my miscarriages took 3 months to pass... which is a big delay when you're old and trying.  For some a miscarriage can lead to a d & c with scarring that prevents future pregnancy. PGT testing doesn't mean you have to discard the embryo-- you can still decide later that you're willing to transfer it if that's you're concern about a false positive.  [/quote]
Yea i get that with the amh,[b] it wont improve quality but hopefully gives us more eggs to increase chances that one would be normal[/b]. I agree with you that those options are not optimal and im more leaning towards testing now. Thank you . Did you test the embryo that you miscarried and did you know why it happened? [/quote]

Is this OP?  I'm confused by this reasoning if you're not considering PGT-A - would you just plan to implant embryo after embryo and see what takes/what comes back okay on the NIPT?  That's an expensive and potentially devastating Plan A.  Conversely, if you think you're going to get a lot of embryos, the idea that there might be false positives from testing seems not as disqualifying as if you were expecting one or two.

Lastly, I just reread the thread and saw something I missed the first time - your RE saying that embryos with chromosomal abnormalities mostly won't implant, and for the few that would you can test early for them.  I find that attitude to be bizarrely cavalier in general, and especially troubling when her patient is 42 years old.  I know multiple people IRL (and thousands more from infertility boards) who have had to terminate for trisomies.  One of my good friends had two healthy kids in her early thirties and then two back-to-back trisomy pregnancies TFMR in her late thirties / early forties.  Chromosomally abnormal embryos absolutely do implant.  And I am 100000% pro-choice, but the idea of going through the IVF process and actually getting a positive pregnancy test and then, 3-4 months later, having to terminate, grieve that loss, and start over, is horrifying.  Even if you think you'll be able to maintain emotional distance until tests come back clear, you don't really have time to do that at this age, certainly not repeatedly.[/quote]

Thank you for sharing. I am considering all of these things which is why im leaning more towards testing now. My RE did say that the trisomies would implant so im aware of those and we talked about turner and Edward syndromes as well. I appreciate all these perspectives and they are giving me pause . I definitely wouldn’t want to go through a miscarriage that could be avoided. What do you think about all the false positives? [/quote]

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