Reply to Large study shows SSRIs work for only 15% of patients, huge placebo effect

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[quote=Anonymous][quote=Anonymous]I’ve been on 3 different meds. First helped a little but really messed with my libido, so I stopped. Second works great—life changing (no more pmdd or crying at the dinner table or feeling like I’d rather die than live another day). Third seemed like a sugar pill—no side effects but also no benefit. I guess I only had placebo effects for the second.

(Isn’t it kind of weird for people to say the negative emotional side effects are real—but not the positive effects?)

I guess I need to not feel so defensive—maybe I’m in the 15%. But these studies do make me feel invalidated, like my anxiety/depression is made up.

I’d also like to add that I became severely depressed each time I was on birth control pill. But very horny. Same with when I have bad PMS: horny—but also a depressed psycho. It’s not great to be horny when nobody wants to have sex with you. My point is that the SSRIs do diminish my sex drive but they also even out my moods. There just has to be a some sort of connection there. At least for some us us. [/quote]

Yeah, I feel you - how could a drug that has such OBVIOUS effects on so many systems be ineffective?  For me, it was zero libido, nonstop dreams all night, weight gain, gross stomach issues.  And the withdrawal was brutal, three weeks of vertigo, sensitivity to noise, crying and irritability.  They do something to the brain, that's for sure!  My subjective belief is that for me, Lexapro makes me more positive and less reactive. But who knows, maybe the same thing would happen on placebo. And, as consumers and patients, we do deserve to know that nobody really knows how the meds work.  "It's just brain chemistry" is an advertising logo, not an explanation.  [/quote]

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