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[quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous]Immediate PP again. Good luck! And also ask about sperm DNA fragmentation while you're there. It's uncommon, and not totally accepted by REs in this area, but research is showing it can cause recurrent losses as well. It's an extra test on top of the standard semen analysis and pretty expensive (I paid $450 including shipping a cooling tank), but another thing to check.

4 miscarriages in 10 months would make me suspicious that there's something more than just age and bad luck going on. Testing for uncommon RPL causes can be a real rabbit hole, but could be the deal breaker for being able to have a second child.[/quote]

Thanks! This is op. We are doing dna fragmentation from my husbands blood. Is there one for semen too?

I have asked about testing for endometritis infection but doctor told me that’s more associated with failure to conceive and not miscarriage. We shall see what happens this next cycle and see how to proceed.

Thanks to all for the support and advice [/quote]

DNA fragmentation is an advanced semen analysis. I think you're thinking of karyotyping, which is a DNA blood test. The DNA frag test looks for DNA damage within the sperm - so the sperm can look healthy on the outside, but stress (increased temperatures, lifestyle factors, bad luck) can cause the actual DNA to become damaged and break. The egg can repair a certain amount of sperm DNA damage, but after a certain point it isn't fixable and can cause embryos to die in the lab, or faulty embryos that fail to implant or cause miscarriages (or even genetic defects with live birth).

And there is simply not enough science for your doctor to say endometritis does not cause miscarriage. That's simply wrong and your RE being selective with the available research. My conservative RE agrees that it is not fully established science, but there is sufficient evidence to test and treat after recurring miscarriage. It is a standard part of the recurring pregnancy loss panel of tests at this point, so I'd really push back on your RE about that. The biopsy hurts, but that's up to you to decide if you think the test is worth it (and IMO it is).[/quote]

Thank you for clarifying. Yes I did mean karyotyping . Sorry about that! I didn’t know about the semen test. I shall inquire! I’ll revisit the endometritis discussion next time I see my RE. Thanks for the encouragement. [/quote]

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