Reply to Next steps after 3 failed PGS normal FETs?

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[quote=Anonymous]OP here again! I am so glad this story has given some others a bit of hope. We're heading into 18 weeks (yay!!) and I am getting nervous for our 20 week scan.

For poster 09:15 (GW patient who did the EFT) the ERA is indeed different, as it doesn't have anything to do with the quality of the lining -- it's measures whether the amount of progesterone support in your system is enough/too much to support successful embryo implantation and growth. If your progesterone is "off" as you said, it will always be a problem and always prevent a successful transfer because your doctor won't know to adjust the dates. My "mock" biopsy cycle only took about a month, not three months - I did it in between a failed FET and the next FET. And I was definitely annoyed to have to spend time doing that rather than move on to another attempt, but I am very glad I got the reassurance that the days of progesterone were calibrated correctly. When I asked my RE for data to convince me it was worth doing it, he said that this past year he had 14 patients out of 78 tested come back as either pre-receptive (too soon), or post-receptive (too late), after doing the biopsy. With being OOP and it being tough to get PGS normal embryos, I didn't want to risk it.

16:46: I am so incredibly sorry to hear about your D&C and losing the pregnancy when you finally got your hard-won PFP and made it all the way to 8.5 weeks. It's heartbreaking! It does sound like it may have been something that could get picked up in PGS testing, so I would definitely do that if you can for your next cycle(S). My second round I had three embryos that came back as trisomies (18 and 22) after testing our five, 6 day blasts that made it. The first cycle, only one out of two was normal because the other one was a trisomy also. So, if any of those four with trisomies had been put in, they would have resulted in a similar miscarriage or need for termination, eventually. But we wouldn't have known that without PGS.

18:04: There definitely seems to be something to fresh transfers working in some women where frozens never "take"! I have seen that on many board posts about multiple failed FETs. That was actually going to be a plan B for our next cycle that I was going to demand we do, until this one unexpectedly worked. (of course, then there is the flip side where you can't do PGS testing on fresh transfers... but still totally worth it as a different tact to try, especially since PGS is not 100% and can misidentify normal embryos).

13:06: Thank you for the kind words! See middle of page 2 for my crazy update - we finally got good news. :)  [/quote]

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