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[quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous]I just reconnected with a group of college friends and we met up for dinner. Every single one looks fantastic - maybe even better in their mid 40s than their 20s. I came to find out that 3 of the 4 women are on GLPs which helped them lose 10-20 lbs (none were overweight) and now they are just micro dosing to maintain. They all said they feel better then they have in years, didn’t have bad side effects, and focus on eating protein so they don’t lose muscle.

Anyway, here I am struggling to lose 10-15 lbs like always - restricting my calories, working out a ton, etc, and barely seeing the scale move. Every time I do lose it it ends up coming back again.

[b]Just wondering why I don’t take the easier route like so many others.[/b] I would need to find a doctor to prescribe it since my PCP won’t (despite telling me my BMI is too high and I need to focus on losing 10-15 lbs).[/quote]

This is why no one talks to you about it. You are a judgey friend.  No one needs that in their life. [/quote]

Not OP but it’s true. It is the easier route. Exercising hard annd regularly at the same time as restricting calories when you work full time and are raising kids is hard. Injecting yourself with weight-loss drugs that work = easy.[/quote]

Ok I'm going to blow your mind here. I've been getting up at 5am to exercise 5 days/week (3 days lifting, 2 days cardio) and walking at least 8k+ steps per day for 3 years. I've dutifully tracked macros nearly every single day. I meal prepped breakfast and lunch and thoughtfully planned dinners. I lost 12 pounds and then got stuck for 2 years+.

I'm on Zepbound now and [i]I still do all of those things.[/i] But now, I've dropped 14 pounds in 2.5 months-- on a "starter"-- not even therapeutic dose. I'm sure there are people who use it to suppress their appetite and when they do eat, eat like shit and don't exercise. But my point is for those of us trying to make lasting changes that support health its STILL hard, albeit admittedly not as frustrating as it used to be. [/quote]

Your story is making me question how healthy all of this is. If your body is fighting you this hard to keep pounds that you have to drug yourself to lose weight, how healthy is this drug? Maybe you shouldn't be losing this weight and the doctors are actually wrong about all of this. Wouldn't be the first time doctors got it wrong.[/quote]
It’s a fair point and something I reflected on for ~6 months while considering taking them.

I’ve also been thinking about the mechanisms of action. I get that most people just don’t eat when they’re on them, but I’ve been very intentional about getting adequate nutrition. I’m eating on average 300 calories less per day than when I wasn’t on them. By that math I should be losing 1 pound about every 11 days. But I’m losing ~1.5 per week which makes me wonder if there’s some metabolic or biochemical process that’s broken in me that this is somehow repairing. My doctor reflected on this too saying she had many folks (mostly women) who are having similar experiences. Her hypotheses were about chronic dieting causing damage or possibly food supply issues. All of my labs in terms of hormones, insulin resistance, thyroid, etc were good, so there’s no obvious explanation.

The thing that pushed me over the edge to do it was that my labs were starting to deteriorate a bit. My LDL was too high and HDL was too low even with typical lifestyle modifications and they have been creeping in the wrong direction. 
[/quote]

Thanks for this response. It makes a lot of sense.[/quote]

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