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[quote=Anonymous]Especially in older adults, there are some concerns regarding sarcopenia, and even dementia:

[i][b]Are we trading an obesity epidemic for a frailty epidemic?[/b]
Dr. Rostova: “We are certainly walking a tightrope. The cardiometabolic benefits of losing visceral fat are undeniable—we are reducing heart failure, liver disease, and systemic inflammation. However, the medical community initially viewed GLP-1s as a standalone cure. We now know they are merely a metabolic catalyst. If you prescribe these drugs without simultaneously prescribing physical movement, you are absolutely accelerating physical frailty, particularly in patients over 60.”[/i]
https://harvardsciencereview.org/2026/02/23/the-glp-1-aftermath-what-the-science-says-about-muscle-loss-and-cellular-aging/

[i][b]Long-Term Risk of Cognitive Impairment with GLP-1 Analogues in Older Adults with Type 2 Diabetes Mellitus [/b]
Among older adults with type 2 diabetes, GLP-1 analogues were associated with an increased risk of cognitive impairment secondary to a larger, decreased risk of mortality. However, caution may be warranted in prescribing GLP-1 analogues to the oldest patients.[/i]
https://www.aan.com/msa/Public/Events/AbstractDetails/65026
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