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Diet, Nutrition & Weight Loss
Reply to "Europe investigating suicidal thoughts with weight loss drugs"
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[quote=Anonymous]I'm not going to read all the back and forth arguing, so apologies if someone has already said this. But it's honestly not surprising that GLP-1 agonists could have this effect on some people. There are lots of GLP-1 receptors in the brain and they have been implicated in reward processing. This is probably why GLP-1 agonists are more effective than other weight loss drugs. These agonists reduce craving/wanting and rumination about food. Some people taking it have lamented that they don't enjoy certain food/drink the way they used to. It stands to reason that GLP-1 receptors could trigger an anhedonia of sorts in some people for reasons we don't yet understand. As more studies are done we will find out more about the effects of these drugs on brain circuits important for reward, emotion, and mood regulation. [/quote]
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