Reply to Husband has Sickle Cell gene and didn't tell me

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[quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous]I am a carrier of the trait, as was my mom.  My mom told me I was negative so I was totally surprised when I came up positive during my pregnancy labs.  This is not a big deal and not worth you getting an amniocentesis over.  Your child has a 50 percent chance of being a carrier.  One of my kids is, the other isn't.  We need to stay well hydrated and listen to our bodies, that is all.  Please calm down.  And not only black people can have it.  This is misinformation.[/quote] Not everyone that has sickle cell trait is black, but everyone that has sickle cell trait has a black ancestor. They traced the origin of the gene back to one child that lived in Africa 7,300 years ago.

https://www.bbc.com/news/world-africa-43373247

https://www.the-independent.com/life-style/health-and-families/health-news/hidden-black-ancestry-linked-to-rise-in-sickle-cell-blood-disorder-738008.html[/quote]
This is true. This is how there are people that physically appear to be fully European that have sickle cell trait or disease. The African ancestry decreases with each generation, but the sickle cell allele can keep getting passed down. The ancestry won't always show up on an ancestry DNA test either because those tests only go back 6-8 generations. I was taught that we are to screen every patient regardless of what they self-report their background as or what they physically appear to be for this exact reason. Not every medical professional is aware of this or follows this protocol though.[/quote]
[b]This, this, this. I tested positive for sickle cell trait (not the disease). I took an ancestry test, and it said 2.7% Sub-Saharan African. I look fully European (obviously).[/b][/quote]
Here is a prime example of why ALL of your ancestry matters - even the extremely low percentages that you think are insignificant. DNA does not care how low your percentage is. You can be 1% African and have multiple African genetic markers that have stuck around, such as being a carrier of sickle cell.[/quote]

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