Reply to Leucovorin now approved by FDA--will providers prescribe to ASD kids?

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Reply to "Leucovorin now approved by FDA--will providers prescribe to ASD kids?"

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[quote=Anonymous][quote=Anonymous][quote=Anonymous]The AP has a good summary here: https://apnews.com/article/autism-drug-leucovorin-trump-kennedy-d2b36faef3c4fc1f85e9fa9f958ad6c6

20 years ago researchers theorized low levels of folate in the brain caused by antibodies blocking its absorption could be a cause of autism in some people. But then a study showed non-autistic siblings also had the low folate levels so that theory was kind of abandoned.

Then in 2018 Frye published a study of 48 children showing those that took leucovorin did better than those that didn't. Since then he has had trouble getting funding to do more research on this. Outside of the US 4 other small studies with different methodologies have also shown a benefit.

This year Frye approached the Trump administration hoping to test a new proprietary version of the drug. To Frye's surprise the FDA just approved the use of the existing drug for autism.

Seems like this really does need to be studied more. The FDA approval is just a political move to make it seem like they are doing something when it is not actually meaningful.

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Lord. quacks all the way down. [/quote]

Unethical, perhaps. But if switching up a drug to regain patent protection makes someone a quack, then you're going to have a problem with all of the drug companies.[/quote]

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