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[quote=Anonymous][quote=Anonymous]I began Wegovy in April of 2024, so I've been on it almost 2 years. I've lost about 75 pounds and have gone from an obese bmi (I think it was 34) to just within a "normal" bmi. It has not been easy -- side effects have been very rough for me. The GI stuff, (diarrhea bad enough to have accidents multiple times and bad constipation including impactions), yes, but the worst part was the fatigue. Debilitating fatigue. It got better as time went on, but was always bad enough to be a problem until I went down in dose to a maintenance dose a few months ago. I have, however, now put 5 pounds back on at the maintenance dose, and I do not like that trend. Saw my doctor this week and may go up in dose if I gain any more weight this month. It scares me though, because I don't want to deal with the side effects getting bad again. My doctor suggested trying zepbound, but my insurance doesn't cover it and even though my insurance coverage on Wegovy isn't great, there is some, and it costs significantly less than zep would cost me. And Wegovy is a known thing for me -- meaning I know it works.

It's all worth it to me to not be obese anymore. But it has not been a bed of roses. And I plan on being on the drug (or a GLP1, anyway) for life. My new fear is that the efficacy just totally wears off for all of us eventually. We'll see. Hopefully not. [/quote]

My sister has had a similar experience. She has insulin resistance and PCOS and had tried hard for years with diet and exercise but her body just doesn’t respond. Wegovy has been the only thing that has allowed her to lose weight.  But like this poster, certain doses have caused great fatigue, nausea, and vomiting. When she went to a very low maintenance dose she had some weight creep back. So she’s currently on a higher dose but not as high as at the height of her weight loss. [/quote]

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