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[quote=Anonymous][quote=Anonymous]I’m in my 60s and have had rosacea forever. Metronidazole never did anything for me. Prescription azelic acid used to help but doesn’t help much anymore either. The most effective thing for me was taking low dose doxycycline worked wonders for me. A very expensive version of doxy was marketed hard years ago but it’s a rip off.

As I’ve aged my rosacea is much worse. I make my own primer and have to use very basic makeup. All chemical sun screens cause me to react terribly. I can’t use any “active” beauty products- no vit c serums or tretenion etc.

[/quote]

You probably have SIBO.

Doxycycline is keeping the methane-producing bacteria in check, which means your rosacea is not as bad.

But, you are never really getting rid of the SIBO because Doxy is not the ideal drug to eradicate it.

"According to the North American Consensus from 2020, oral antibiotics play a key role in SIBO eradication [11]. The purpose of antibiotic therapy is not to eradicate completely (which is not always possible) the bacteria colonizing the small intestine but to modulate the small intestinal microbiota in a manner that leads to improvement of SIBO symptoms. Most studies on SIBO treatment have evaluated the efficacy of amoxicillin with clavulanic acid, ciprofloxacin, doxycycline, metronidazole, neomycin, norfloxacin, tetracycline, co-trimoxazole, or rifaximin [32]. In light of the lack of large randomized clinical trials evaluating the effects of antibiotics in the treatment of SIBO, antibiotic therapy is usually empirical."

Rifaximin is the drug used by GIs.

"Recently, rifaximin has been increasingly used in the treatment of SIBO [34,35]. Rifaximin has a good safety profile, is not absorbed from the gastrointestinal tract, dissolves well in bile, has broad-spectrum antibacterial effects against Gram-positive and Gram-negative aerobic and anaerobic bacteria, and its side effects are comparable with those of a placebo. What is particularly noteworthy is the fact that, according to studies, rifaximin acts like a eubiotic in the gastrointestinal lumen, which means that it protects the intestinal microbiota and increases the number of beneficial bacterial strains of the genera Lactobacillus and Bifidobacterium, reduces inflammation, augments intestinal barrier function, and limits bacterial translocation [36]. Another valuable characteristic of rifaximin is the fact that it does not produce bacterial resistance, and therefore, can be used again (provided the necessary interval of at least four weeks is maintained between consecutive 14-day courses of rifaximin treatment) [37]."

Source:
https://pmc.ncbi.nlm.nih.gov/articles/PMC9604644/[/quote]

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