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[quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous]Why aren't clinics just doing full genome sequencing? Wouldn’t it be nice to know an embryo’s risk for cancer, low iq, mental illness, etc? 
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Full genome sequencing is very expensive for embryos. The DNA samples collected from PGT only include a handful of cells (2-5 range) this DNA needs to be amplified many times then sequenced 30-50x to ensure an acceptable level of accuracy.  The only company that offers whole genome sequencing for Embryos charges $2,500 per embryo. If you have ten embryos that is $25k just for DNA sequencing. This genetic testing can effectively double the cost of an IVF cycle . [/quote]

Right, but the return on the investment could be 100x. It’s a lot cheaper than college. If you have a healthy baby with low risk for developmental, cognitive, mental, and physical disorders you can save you and the baby hundreds of thousands of dollars over a lifetime. I don’t understand why this is not done as standard practice. [/quote]

Most genetic traits are polygenic and the genetic correlation between traits is generally weak. The genes conferring these traits are inherited randomly with 50% from each parent. It is unlikely that you will get an embryo that has a genetic royal flush, with a high predicted IQ, low risk for all major mental disorders, tall, and low risk for most diseases. The major limiting factor for the efficacy of polygenic selection is the number of embryos. With the best (currently available models), the average expected gain for embryo selection based on predicted IQ score is 4-6 points if you pick the highest scoring out of 10 embryos. If you have 50 embryos and pick the best scoring one, the average expected gain is 7-9 IQ points. Unfortunately, the embryo that has the highest predicted IQ score is not likely to be the one that also has the lowest risk for heart disease and Alzheimers. Unless you have 100's of embryos or even thousands, it is unlikely that you will get an embryo that has a significantly higher predicted IQ than the parents which is also low risk for most major diseases. In my situation, I had less than 10 embryos and the range in predicted IQ between the highest and lowest scoring embryo was only 5 points. [/quote]

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