Reply to up to 40% weight reduction from muscle loss with GLP1s?

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[quote=Anonymous][quote=Anonymous]The study showing that close to 40% of weight lost was lean muscle is discussed in this article.

[url]https://www.healthline.com/health-news/ozempic-muscle-mass-loss#What-the-science-says-about-sarcopenia-and-GLP-1-drugs-like-Ozempic[/url]

Here is what an expert had to say (with emphasis added):

[quote]Data that is raising concern about sarcopenia as it relates to GLP-1 drugs is driven by a small portion of participants who underwent DEXA (dual-energy X-ray absorptiometry), which measures bone mineral density using spectral imaging, said Dr. Karl Nadolsky, endocrinologist and diplomate at the American Board of Obesity Medicine.

“Of this subset, the total mass loss was nearly 14 kg and while nearly 8.5 kg (about 60%) was fat loss, the 5 kg lean mass loss reported was 38%, which is on the high end of what we’d expect,” he told Healthline.[b] “That said, DEXA is certainly imperfect in splicing the details of this body composition change as adipose tissue includes plenty of ‘lean mass.’ Additionally, the placebo group lost more lean mass (-1.83kg) than fat mass (1.37kg), which shows potential error.”
[/b]
[b]Nadolsky pointed out that rapid weight loss, in general, will reduce resting metabolic rate to some degree.[/b]

For instance, a meta-analysis showed that people who underwent bariatric surgery demonstrated over 8kg of fat-free mass and lean body mass loss within 1 year post-bariatric surgery, which reflected 21% and 22% of total body weight loss, respectively.

“Any time people lose weight, one-quarter to one-third of that weight can be muscle, and the faster we lose, the more likely we are to lose muscle. While 20% reduction in muscle mass seems normal for someone losing weight, the problem is the length of time in which this muscle loss occurs,” said Kumar.[/quote]

The jury is still out on this, but the article has advice on how to minimize the loss of muscle mass while taking these medications.[/quote]

The advice on eating protein and weight training is very good advice. The part about just a small amount of people getting scans, and these are people who have experienced rapid weight loss, makes it so that I think that the many people who have more slower weight loss probably aren't getting the scans and losing so much mass.

The article also pointed out the at least 20% lowering of risk of heart attack, heart disease and stroke.[/quote]

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