Reply to Is there anything new in the nut allergy treatment world?

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[quote=Anonymous][quote=Anonymous][quote=Anonymous]Yes!!  Xolair - our allergist said we can expect FDA approval in Q1 or Q2 of 2024.  It’s a once-monthly injection that substantially reduces risk of a severe reaction.  There’s another one in clinical trials now that has an even more dramatic effect.  And what’s really cool is that a PN-allergic kid could take it during risky times, e.g., high school, college, but wouldn’t need to as a responsible adult with their own kitchen.

This allergist (Mark Scarupa at Institute for Asthma and Allergy) is also not high on OIT, for various reasons.  But he was positively giddy about these options.  It felt like a bit of relief for my 10yo PN-allergic DS.[/quote]

Interesting. DS sees Dr Scarupa for peanut allergies and at his last visit in August, right before he left for college, Dr Scarupa didn’t even mention this. [/quote]

That's too bad.  He always discusses the latest research at our appointments.  I work at NIH and so we've talked shop a bit before, but that shouldn't matter.  He told us this info in June, maybe he changed tactics in discussing it in between then and August?

With respect to early introduction, allergies are NOT solely determined by genetics, but rather by gene-environment interaction.  As a PP said, it reduces the risk for development of allergy, but it's not a guarantee.  Interestingly, my PN-allergic son was just a tad too old to benefit from findings/updated clinical guidance from the LEAP study.  Scarupa was very candid with us after the fact, "we gave you the wrong advice."  He was also adamant that our youngest (2.5 years younger than the PN allergic kid) be exposed early, which we did.

Last but not least, his hesitations around OIT were mostly logistical, but he also said that many kids who do it feel sick from the allergen (even if they don't have a true reaction) and also that many develop a strong aversion to the food in question.  DS doesn't want to come anywhere near peanuts, so I can imagine it would be a struggle to get him to try a bit, especially since he would have to have it regularly, indefinitely, to prevent loss of tolerance.

Still excited for Xolair.  I know it's not a cure, but reducing risk of anaphylaxis is huge.[/quote]

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