Reply to Transitioning from Retinaldehyde to Tretinoin

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[quote=Anonymous]Hi there.  I am confirm the effectiveness of Avene RetinAL 1% (Avene) which contains  RETINALDEHYDE. I'm  caucasian, Fitzpatrick 3/4 with dry skin. Been using for over a year and have terrific skin, but saw skin texture and tone results within 6-8 weeks on Avene..and i'm talking like really noticeable  diminishing of sunspots / chloasma and nice smooooth skin. I couldn't stop touching my face it was sooooo soft. Unlike TRETINOIN (TRET), RETINALDEHYDE is a natural product that, while taking a little longer to see noticeable results in terms of sagging, giving lift, reduction of nasiolab. folds, and working on the deeper skin conditions where the real ageing takes place, studies have confirmed it is just as effective  as TRET 1% (a synthetic product)..but.. only if you stick with it...and give it time..like they say...a RETINOID program is not a sprint, but a marathon. Ive recently wanted to try TRET to see whether it stands up to the hype, so i started  on TRET 0.025% about three weeks ago, using every second day and alternating with my Avene.  I've never had issues with flaking, peeling, redness or irritation ...ever....and I put it down to the "starting slow and working up" method, so i havent had any transition issues with the TRET. But I can confirm to someone's previous post that I alternate every other day between the two without issue.  RETINALDEHYDE converts into Rentinoic acid in the skin quite quickly (only 1 conversion step to provide the magic in the skin) so there doesn't  appear to be any conflict between the two because the conversion of  RETINALDEHYDE happens almost as quickly as yhe immediate conversion of the TRET. Ive read somewhere that RETINOL shouldn't be used with TRETINOIN because (a) very irritating and (2) it converts to RETINOIC acid in the skin a lot slower (two conversion steps..much much slower than retinaldehyde) ..and before it gets a chance to do its thing, the TRETINOIN (immediate no conversion) has already provided the RETINOIC acid in the skin, so the RETINOL is in effect, wasted. There you have it. Ill put a couple of useful SCIENTIFIC STUDY links on RETINALDEHYDE in so you can read about it. Its terric stuff..affordable, can get it without  a script, no purging issues, and for the most part, more gentle and less irritation than TRET. If I was starting out that would be my "go to" if you want a "no hassle" intro into the RETINOID family. Oh yes..no matter which member of the RETINOID family you choose to use, a big tip! Theres recently been a lot of ladies presenting to dermatologists with dry and irritated eyes. RETINOIDS apparently can ruin the delicate tear glands in your eyes (ever noticed your eyes are stingy and water within moments of applying?) Make sure to use a cotton bud (aka q-tip) and smear a bit of vaseline or similar occlusive around your eyelids, edges of nostrils, around mouth, and along the rings of venus (if you're like me and do your neck and decolletage) to prevent drying  and irritarion in those delicate areas. RETINOIDS travel 2 inches under the skin out from where you apply it, so be careful. These delicate areas are called deadzones because the RETINOID, when it reaches those areas has nowhere to go and pools in the crevices. All the best and happy skincare!

Cheers! J

https://pubmed.ncbi.nlm.nih.gov/25607905/

https://pubmed.ncbi.nlm.nih.gov/7798613/

https://pubmed.ncbi.nlm.nih.gov/29663701/

https://pubmed.ncbi.nlm.nih.gov/30027612/

https://pubmed.ncbi.nlm.nih.gov/10473963/

https://pubmed.ncbi.nlm.nih.gov/10473955/
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