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[quote=Anonymous][quote=Anonymous][quote=Anonymous]I’ve posted before so I don’t want to repeat because someone will think I’m a drug rep but here goes. I was included in a study conducted by NIH for semaglutide for almost 2 years. Started Nov. 2018. Starting weight was either just over 300lbs or just below, can’t remember and I don’t want someone to dig up one of my old threads and call me a liar. But it was somewhere around 300lbs. Ended the study Nov. 2020 @ 182lbs. Lowest weight was June 2020 167lbs. I wanted to be 170 by my 50th Birthday. I purposely gained weight back because I thought I looked gaunt at 167. Just looked too thin in the face. I thought I looked like someone who had lost weight due to illness.

By February 2021, I was back up to about 225lbs. But honestly, I wasn’t trying to maintain, COVID isolation was getting me down, my mom was severely ill with Covid-19, I had started a second job, stopped going to the gym and just generally DGAF. But by March, I was ready to get back at it.

My doc from the study then prescribed Rybelsus 14mg (the diabetic flavor of the medication). Current weight is 192lbs. Goal weight is between 177-180lbs.

While I was in the study, they basically told me that this would be a lifelong drug. Or until I stopped caring about my weight.

Side affects: Some nausea, feeling cold all the time, some diarrhea in the beginning, and when you are full, you are full, your belly won’t take another bite or you will be miserable until you poop it out.

The dosing was gradual. Started with .25mg to top dose of 2.4mg.

This medication is not at like phen-fen or any type of stimulant.

It is expensive, but the manufacturer has a coupon to cover the first 6 scripts or at least they did on the Rybelsus.  My doc has written me a script for the Wegovy, but it is very hard to find. I’ve been trying to get it for 6 weeks.

If anyone wants to know more from my experience from being in the study I’m more than happy to share. Also search Semaglutide in the diet forum and you will find a couple of the threads that I’ve talked about my experience.[/quote]

Thank you so much for this helpful info.  What did you do about the nausea?  What did you feel like when you went off the medication?  Did your appetite come roaring back? Are you able to live normally (like exercise, sleep, etc)?  [/quote]

I just lived through the nausea. Not gonna lie it was rough. It would wake me up at night. And sometimes it came on really strong out of the blue with no fore play, One time I was in Target shopping, doing fine and it hit me, I thought I was about to pass out. My daughter had to drive home and she was unlicensed! I was like take me home now! But as quick as it would come, it could pass equally as fast, but you don’t know that at the time. The nausea stopped about 6-8 months after starting the medication. And honestly, I was losing so much weight, I didn’t really care, when the study coordinator asked me about it, I said it was manageable.

I felt completely normal going off the medication. Meaning, sleep normal, exercise normal, no crazy thoughts, no depression or thoughts of hurting myself (that was a main concern during the study).

My appetite did not come roaring back, but cravings did. My appetite was insatiable. What I mean is, I wasn’t gorging on food in one sitting or stuffing myself but  I was never satisfied with anything I put in my mouth :wink: I would eat two bites of a hamburger, no that’s not what I wanted, piece of chicken, nope, not that, slice of pizza? Nope. Ramen noodle? No. Watermelon? Halo mandarin? Oreo cookie? Toast? Boiled egg? You get the picture. And this would happen all in one night! I was going through this every day! I was hitting the grocery store every day buying all types of $hit trying to figure out something to satisfy my appetite! It was driving my husband crazy, I was gaining weight, plus COVID isolation, no gym, and just wanted to get control of my appetite.  My once favorite foods didn’t seem gave me what I wanted or needed emotionally or otherwise. My stomach would be full, but my brain was constantly searching for something…..it was the worst feeling, even at 300lbs I had never had these types of feeling about food before. It had me in F’ing tears.

So I know all of that sounds bad, but I wanted to be honest. When I got back on Rybelsus (the pill) my doc added Topiramate er 50mg. That definitely has controlled the cravings. My weight today is 188lbs. I exercise 4 days a week split of 2 hours strength training and 3 hours cardio.

One thing to add about my appetite and being not satisfied, I would be full with a reasonable amount of food, meaning physiologically the medication seemed to train my stomach to know how much food was enough, it was my brain that still wanted more. It wasn’t my belly. I wasn’t hungry, I just wasn’t satisfied, just wanted to say that.

I finally was able to get my script filled for 2.4mg of Wegovy. Paid $25 with manufacturers coupon and insurance (1 month supply). Will start it next Tuesday. I have to be off the Rybelsus pill for a week.

TLDR; Pushed through the nausea. Generally normal after the medication stopped. Sleep, exercise and mostly normal mental state. Cravings were unmanageable and hit me like a freight train in a bad action movie. [/quote]

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