Reply to Wegovy/Saxenda for weight loss?

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[quote=Anonymous]NP here. I've been on 0.5 mg of Wegovy for four weeks through Calibrate -- it took me a couple of months after joining Calibrate to finally get it with the coupon. I don't have diabetes and insurance would not cover any brand of semaglutide.

I've yo-yo'ed a lot in weight over the last 25+ years, from 135 at my lowest to probably 190 at my highest (5'4", big frame, I'm never going to be skinny). I simply cannot eat any non-vegetable carbs, or my weight shoots up, so falling off the low-carb bandwagon over the past couple of years (and then a new sourdough habit during the pandemic) pushed me right back up the scale again.

I started Calibrate in early July at 184 (I'd already gotten back on the low-carb train and probably dropped 5 pounds on my own before starting). I was immediately started on 500 mg metformin but didn't get Wegovy until exactly 4 weeks ago. From July to September I lost about 8 pounds and in the month of September alone I've lost another 8, so I'm down to about 168.

I have definitely had nausea -- the first night I took it, the nausea woke me up at 2 am -- although I've never vomited. I've taken some Zofran to manage the nausea when it's been bad but it usually seems to abate in a day or so after my weekly dose.

I hope to God I can stay on this drug. It is the first time in my life where I'm not suffering from food cravings or, like PP, beating myself up for not being able to resist food. I'm just not that interested in eating, and I'm not focusing on when and what my next meal is going to be. It's easy to stay low carb (their diet plan is essentially low to moderate/slow carb, nothing crazy) because I'm just not hungry. There's (really good!) ice cream in the freezer for my spouse and kids, and I just don't care.

For me, the diet plan and coaching on Calibrate are OK but what's really making the difference are the drugs. I have a very strong family history of Type 2 diabetes and taking this drug is 100% worth it for me to free myself of food cravings and drop the weight so I'm not as metabolically at risk.

Also, I have papillary thyroid carcinoma (I'm in an active surveillance program and have no intention of getting surgery). The thyroid cancer potentially linked to GLP-1s in rodent models is medullary thyroid cancer, which is far rarer than papillary thyroid carcinoma, the most common kind. (There are also two other kinds of thyroid cancer.). I'm personally much less concerned about getting another kind of thyroid cancer than I am about the very real risks of diabetes and obesity.[/quote]

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