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Infertility Support and Discussion
Reply to "Transferring abnormal embryo?"
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[quote=Anonymous]OP, I'm actually with you on the gender selection aspect (I get that that's an unpopular view here). Are these aneuploidy (i.e. all cells tested were chromosomally abnormal) or mosaic (i.e. some cells chromosomally abnormal, other cells normal)? With mosaicism there's also different degrees (what percentage of the embryo is estimated to be aneuploid) and outcomes vary depending on which chromosome is affected. Make an appointment with a genetic counselor. If you clinic doesn't have one, get the details of which chromosomes were affected and how complex the mosaicism was for each embryo, and bring that information with you to the appointment. She will be able to give you far more specific information about how likely survival is for your embryos, and what you're risking with each, if the abnormal cells end up predominating. Many chromosomal errors are incapable of producing a baby - you will miscarry. In others, there could be a baby born, but depending on the chromosome the child may be severely disabled. On the other hand, many healthy children are conceived naturally and only later found to have mosaicism. And up until very recently no embryos were PGS tested at all before transfer, so we were deliberately transferring some aneuploidy embryos along with euploid ones. This is still the case for fresh transfers and those who choose not to test. OP, for what it's worth I would sit of these abnormal boys for now and do a second retrieval. Pay for the storage and you can always transfer them later if it still doesn't work out. I don't know how recently your 5 PGS normals were conceived, but if you can produce multiple healthy blasts you've got a real shot at getting a PGS normal boy or two in the next batch. [/quote]
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