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[quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous]Also your estradiol was always too high, so your FSH was probably over 10 at 38 which is bad.

I was incredibly lucky to have gotten pregnant several times starting at 38. My AMH was low throughout (all my IVFs failed) but my FSH was always under 10 and my estradiol was in low 20s even at 44.[/quote]

I thought low estradiol is bad.  Can you explain why high estradiol levels are bad?  I'm unclear about this.

Also my FSH between age 38-40 ranged from 5-10 on the three times it was measured during those ranges but still no luck in getting pregnant.[/quote]

only the highest FSH is relevant. high FSH indicates that eggs are not signaling well which they think is related to their quality. if you hit 10 at 38 that would indicate low quality for your age.

as for estradiol, it masks your FSH making it seem lower (i.e. better) than it is. so if you FSH was 8 while your estradiol is 40s that means your "real" FSH is more like 10 or 12.

this is independent on whether high estradiol is good or bad. the point is that it makes FSH (which is more important) look better than it is and needs to be taken into account.

as for estradiol itself... low is not good when combined with other hormones which indicate menopause. however, i think the doctors don't quite understand the levels and how they relate to infertility. my own hunch is that estradiol needs to be low (e.g. low 20s) but also climb very sharply before ovulation.[/quote]

OP here.  Okay, so if an FSH of 10 at age 38 implies low quality eggs for my age, how did I get pregnant on the first try at 36?  I have no idea what my hormones were at 36 when I got pregnant because I didn't have an infertility problem then.  Is it possible to have normal fertility for my age at 36 and then two years later be completely infertile?  This is what I don't really understand, how the decline could happen so sharply.  My AMH at 38 was .60 which is already low.  At 36 could it really have been that much higher?[/quote]

it’s obviously possible - I mean you said you were trying all these years with no success. to me it looks like you didn’t have a lot of eggs and also they were low quality. during those two years both things got worse. so maybe you used to have 3 good eggs per year at 36 and then 1 good egg per year at 38 and fewer after that. so maybe you only had 2-3 good eggs to work with since 38.[/quote]

OP here.  Yes, but it just seems to be to be very unusual to get pregnant on the first try at 36, and then be completely infertile at 38 when my baby was only 1 year old.

From 38-42 we did IUIs, IVFs and tried on our own every single month.  How can it be that zero eggs resulted in a pregnancy when it was so easy at 36?  Especially given the fact that my AMH did not change much from 38 to 42, as I listed in the first post.

The RE said that in general AMH declines at .2 per year, but if that is the case then at 36 my AMH would still be under 1, so how did I get pregnant right away then?

It just makes no sense to me that in 2 years things could decline that dramatically when my numbers have been relatively steady since.  Something doesn't add up, but infertility testing, surgery, etc. did not uncover any abnormalities.  I was diagnosed as mild DOR, no male factor.[/quote]

i am not sure what you are looking for here?

here is one scenario consistent with your numbers. you had 3 good eggs when you were 38 and you hit one of those quickly. you would only need 3-4 months for that.

at 38, you have 1 egg in 18 months. you don't get pregnant, go to IVF, then your suppression coincides with the good egg. then you are 40 and have one good egg in 24 months. you miss one cycle. etc.

the point is, if you only have 3 good eggs available in 4-5 years it's easy to screw up, especially if you are using a lot of treatments which might mess up whatever good eggs you might have.

also - AMH is not a great measure. the measurements vary wildly and IT IS NOT better measure than FSH. FSH has a much longer stronger record and and is the the best indicators of fertility that the doctors have though far from perfect. and your has been poor during your attempts and is now in the category where most clinics won't treat you.[/quote]

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